New study identifies possible treatment for metabolic disease

A study published online today in the journal Nature reveals that increased expression of the gene PGC1-alpha increases levels of the hormone irisin. Irisin is responsible for some of the beneficial effects of exercise. The authors found that if they increased the levels of PGC1-alpha, the levels of irisin increased, and gave animals the benefits of having exercised even when animals were inactive. This result could lead to treatments for metabolic disease and other age-related disorders that are typically improved with exercise. Click the title to view the paper:

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

Authors: Pontus Boström, Jun Wu, Mark P. Jedrychowski, Anisha Korde, Li Ye, James C. Lo, Kyle A. Rasbach, Elisabeth Almer Boström, Jang Hyun Choi, Jonathan Z. Long, Shingo Kajimura, Maria Cristina Zingaretti, Birgitte F. Vind, Hua Tu, Saverio Cinti, Kurt Højlund, Steven P. Gygi & Bruce M. Spiegelman

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