Evidence against the oxidative stress theory of aging?

Recently we have seen a crop of evidence showing up that the oxidative stress theory on aging isn’t all it was cracked up to be. At the very least, oxidative reactions and the repair of their damage are more complex than originally thought. This article was selected as a “must read!” by an expert (E. Rial) on Faculty of 1000’s service and featured via their facebook page this morning, indicating that the experiment is done well. For those of you who don’t have access to the F1000 service (Get it! You won’t be disappointed!) here is a summary of the paper, given in Rial’s review:

“This interesting paper challenges the current “oxidative stress” theory of aging by demonstrating that the correlations found in the nineties between the rate of mitochondrial production of reactive oxygen species (ROS) and lifespan were the result of the serendipitous choice of experimental conditions.” Rial E: 2012. F1000.com/13258956#eval14611054

This primary research article is through the PLoS journals, so it’s free for everyone to read (yay!):

Montgomery MK, Hulbert AJ, Buttemer WA, 2011. The long life of birds: the rat-pigeon comparison revisited. PLoS ONE 6(8): e24138. doi:10.1371/journal.pone.0024138


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