Tag Archives: Obesity

Mediterranean-style diet plus Coenzyme Q10 supplement decreases inflammation

Systemic inflammation is a major contributor to age-related dysfunction. Previous research has hinted that a Mediterranean-style died may be capable of lowering systemic inflammation (in addition to helping you drop weight and lowering your risk of metabolic disease). An article published online today shows that a Mediterranean-style diet, plus supplementation with the antioxidant Coenzyme Q10 decreases the expression of genes related to inflammatory response and endoplasmic reticulum stress in people 65 years or older. Mmm… more reasons to eat Mediterranean-style… There aren’t any general news articles about this publication yet, but if you have access through your library, you can get the primary research article here: http://biomedgerontology.oxfordjournals.org/content/current

Elena M. Yubero-Serrano, Lorena Gonzalez-Guardia, Oriol Rangel-Zuñiga, Javier Delgado-Lista, Francisco M. Gutierrez-Mariscal, Pablo Perez-Martinez, Nieves Delgado-Casado, Cristina Cruz-Teno, Francisco J. Tinahones, Jose M. Villalba, Francisco Perez-Jimenez, and Jose Lopez-Miranda. 2012. Mediterranean Diet Supplemented With Coenzyme Q10 Modifies the Expression of Proinflammatory and Endoplasmic Reticulum Stress–Related Genes in Elderly Men and Women. J Gerontol A Biol Sci Med Sci (2012) 67A(1): 3-10 doi:10.1093/gerona/glr167

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New study identifies possible treatment for metabolic disease

A study published online today in the journal Nature reveals that increased expression of the gene PGC1-alpha increases levels of the hormone irisin. Irisin is responsible for some of the beneficial effects of exercise. The authors found that if they increased the levels of PGC1-alpha, the levels of irisin increased, and gave animals the benefits of having exercised even when animals were inactive. This result could lead to treatments for metabolic disease and other age-related disorders that are typically improved with exercise. Click the title to view the paper:

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

Authors: Pontus Boström, Jun Wu, Mark P. Jedrychowski, Anisha Korde, Li Ye, James C. Lo, Kyle A. Rasbach, Elisabeth Almer Boström, Jang Hyun Choi, Jonathan Z. Long, Shingo Kajimura, Maria Cristina Zingaretti, Birgitte F. Vind, Hua Tu, Saverio Cinti, Kurt Højlund, Steven P. Gygi & Bruce M. Spiegelman